Details

Project TitleCOMPOSITIONS COMPRISING NANOPARTICLES AND APOPTOTIC AGENTS AND METHODS OF USE
Track Code2009-006
Short Description

The nanoparticlescan significantly enhance the cancer chemotherapeutic effects of the apoptotic agents

Abstract

Compositions comprising nanoparticles, such as silver or gold nanoparticles or carbon nanotubes (CNTs), and apoptotic agents are described. The nanoparticlescan significantly enhance the cancer chemotherapeutic effects of the apoptotic agents. In particular, a highly increased anti-tumor activity has been demonstrated for the combination of etoposide and CNTs against HeLa cells compared to the administration of either etoposide alone or nanoparticles alone. Data provided by flow cytometry, Caspase 3 and other methods, suggest a strong interaction between the nanoparticles and the cellular structure, which can result in the improved effectiveness of chemotherapeutic agents. These findings provide potential new cancer therapies by carefully selecting the right combination of cytostatic drugs and nanostructural materials which synergistically provide significantly greater curative rates.

 
Tagsnanoparticles, nanotubes, apoptopic agents, caspase 3
 
Posted DateDec 8, 2014 4:40 PM

Researcher

Name
Meena Mahmood
Alexandru Biris

Technology Representation

Technology Applications

-Pharmaceutical industry

-Chemotherapeutic drugs

-Cancer treatments

Technology Advantages

-Increased efficiency of existing drugs

-Reduced toxicity of drugs

-Less toxic effects on patients

About the Lead Researchers

-Alexandru S. Biris, Professor Systems Engineering, Director of the Center of Integrative Nanotechnology Sciences

-Meena Mahmood, Post Doctorate Fellow

Opportunities to Work Together

Intellectual Property

Patent Number Issue Date Type Country of Filing
12/775,210 None Utility United States